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dsq 2 days ago [-]
Does this imply that supplementing with omega 3 can help age related vision decline?
VitalStack 14 hours ago [-]
Not quite, and the distinction matters. Standard omega-3 supplements give you EPA and DHA. This study is specifically about very long chain PUFAs produced by the ELOVL2 elongase in retinal cells — molecules that are downstream from DHA, not DHA itself. The article's phrasing "not just DHA" flags this.
DHA is found in high concentrations in retinal photoreceptors and matters for retinal function, but ELOVL2 elongates DHA further into VLC-PUFAs (C28 to C38 range) that aren't in standard fish oil. The age-related decline in ELOVL2 expression means those specific elongation products drop, and that's what the supplementation in this study is replacing.
Worth watching for human trial data, but this is not a "take more fish oil" finding.
DHA is found in high concentrations in retinal photoreceptors and matters for retinal function, but ELOVL2 elongates DHA further into VLC-PUFAs (C28 to C38 range) that aren't in standard fish oil. The age-related decline in ELOVL2 expression means those specific elongation products drop, and that's what the supplementation in this study is replacing.
Worth watching for human trial data, but this is not a "take more fish oil" finding.
no, no can, could. Or could not.